Lifespan Research Institute

Quercetin: Benefits, Side Effects, and Research

Quercetin is a plant-derived antioxidant found in many fruits and vegetables, studied for its anti-inflammatory and longevity-enhancing potential.

Niacin: Benefits, Side Effects, and Research

Niacin, or vitamin B3, plays a vital role in energy metabolism and may influence aging pathways through NAD+ modulation.

Apigenin: Benefits, Side Effects, and Research

Found in chamomile, apigenin is a natural flavonoid with reported anti-inflammatory and anti-anxiety effects, and potential cellular benefits.

Magnesium: Benefits and Side Effects

Magnesium supports muscle and nerve function, blood glucose control, and has been explored for its role in aging and chronic disease prevention.

Rapamycin: Benefits, Side Effects, and Research

Rapamycin is one of the most studied compounds in longevity science, known to extend lifespan in multiple species by inhibiting mTOR.

Creatine: Benefits, Side Effects, and Research

Best known for athletic performance, creatine is also being explored for neuroprotection and cognitive aging support.

Spermidine: Benefits, Research, and Side Effects

Spermidine is a polyamine that promotes autophagy and may mimic some of the effects of caloric restriction to support healthspan.

Yamanaka Factors: Opportunities for Rejuvenation

The Yamanaka factors (OSKM) can reprogram cells to a more youthful state, holding promise for reversing age-related cellular changes.

Vitamin K2: Uses and Possible Side-Effects

Vitamin K2 is essential for bone and cardiovascular health, and emerging research is exploring its role in longevity and immune function.

Ashwagandha: Benefits, Uses, and Side-Effects

Ashwagandha is an adaptogenic herb known for its ability to reduce stress and anxiety, support cognitive function, and improve overall vitality.

Centrophenoxine: Research, Benefits, and Side-Effects

Centrophenoxine is a cholinergic compound studied for memory enhancement and neuroprotection, potentially useful in age-related cognitive decline.

Improving Sleep Quality for Better Health

Better sleep improves cognitive function, immune resilience, and mental health. This article explores evidence-based techniques to improve sleep hygiene.

Biotin: Side Effects and Benefits You Should Know About

Biotin supports healthy hair, nails, and skin, and plays a crucial role in metabolic processes, although supplementation can sometimes skew lab tests.

L-Carnitine: Benefits, Uses, and Side Effects

L-Carnitine helps transport fatty acids into mitochondria for energy production and has been explored for cardiovascular and cognitive health benefits.

Apple Cider Vinegar: Benefits, Myths, and Side Effects

Apple cider vinegar is popular for purported digestive and weight benefits, though evidence is mixed and high doses may cause side effects like enamel erosion.

Intermittent Fasting and Time-Restricted Feeding

Intermittent fasting may reduce inflammation, improve metabolic health, and influence longevity, though long-term human data is still emerging.

How Metabolic Syndrome Makes Aging Worse

Metabolic syndrome accelerates aging by increasing inflammation and oxidative stress, raising the risk of heart disease, stroke, and diabetes.

Urea Is a Blood Biomarker of Aging

Though traditionally used to monitor kidney health, elevated urea levels are now being investigated as indicators of systemic aging processes.

Red Blood Cells as Biomarkers of Aging

Alterations in red blood cell distribution width and deformability are emerging as potential indicators of biological aging and disease risk.

The Relationship Between ApoE and Alzheimer’s

The APOE ε4 allele is the strongest known genetic risk factor for late-onset Alzheimer’s disease, shaping research into personalized prevention strategies.

Blood Glucose Is a Biomarker of Aging

High fasting blood glucose is linked to insulin resistance and shorter lifespan, making it a key target for interventions in aging biology.

What Alkaline Phosphatase Is and Does

Alkaline phosphatase is an enzyme tied to bone and liver health. Elevated levels are associated with aging and chronic disease risk.

Albumin as a Blood Biomarker of Aging

Low serum albumin levels are linked to frailty, inflammation, and mortality in older adults, making it a valuable biomarker in longevity science.

Hyaluronic Acid: Benefits, Side Effects, and Research

Hyaluronic acid is essential for skin hydration and joint health, with research also exploring its role in wound healing and inflammation reduction.

Butyrate: Health Benefits and Side Effects

Butyrate is a gut-derived short-chain fatty acid linked to improved gut health, reduced inflammation, and possible metabolic benefits in aging.

Alpha-Lipoic Acid: Benefits, Side Effects, and Research

Alpha-lipoic acid is a mitochondrial antioxidant that may enhance glucose metabolism, reduce oxidative stress, and support cognitive and liver health.

Resveratrol: Benefits, Side Effects, and Research

Resveratrol is a polyphenol associated with heart health and lifespan extension in animals, partly due to its activation of sirtuin pathways.

Metformin: Benefits, Side Effects, and Research

Metformin is a diabetes medication that’s being studied for its potential to delay aging and reduce cancer and cardiovascular risk in non-diabetics.

Chondroitin Sulfate: Benefits, Side Effects, and Research

Commonly used for joint health, chondroitin sulfate may reduce inflammation and cartilage degradation, with emerging interest in its anti-aging properties.

Low-Dose Naltrexone: Benefits and Side Effects

Low-dose naltrexone is being researched for its immune-modulating and anti-inflammatory effects, showing promise for autoimmune and chronic pain conditions.

What Is Glutathione? A Summary of Glutathione

Glutathione is the body’s master antioxidant, critical for detoxification, immune health, and cellular repair, with levels declining with age and illness.

How Sleep Apnea Accelerates Biological Aging

Alarmingly common yet routinely ignored, severe untreated obstructive sleep apnea can steal 7 to 8 years of life, second only to cigarette smoking.